Electronic Signatures with SharePoint is not impossible. There are some steps to perform to enable eSignature for your SharePoint Library.
- Web Service for Approval Signatures (https://part11compwithsp13.codeplex.com/)
- SharePoint Configuration
- InfoPath Task Form Modification
- SharePoint Configuration Finalization
How to set up 21-CFR-Part-11 you will find here: http://download.microsoft.com/download/3/6/B/36B2F4F5-55AD-4D64-BC5B-62B536E35A62/SharePoint-2013-Configuration-Guidance-for-21-CFR-Part-11%20v2.pdf
Within SharePoint you are able to identify a Document as signed on a small lock.
The result looks something like this.
Each document now have an option called “Compliance Details”.
On the “Compliance Details” form you are able to get some informations about the audit log report.
Output for an audit log report is generated as Excel document.
You have the following predefined reports available: